Sodium and potassium balance in the Brattleboro rat.
نویسندگان
چکیده
Since its discovery in 1961/ it has become apparent that the Brattleboro (01) rat is a useful model for the study of a variety of physiological problems in addition to the obvious one of the role of antidiuretic hormone (vasopressin, ADH) in urine concentration and water balance. In the study of the control of extracellular fluid volume and electrolyte balance, in particular, the DI rat offers a unique opportunity to observe the spontaneous interaction of homeo static mechanisms when a single disturbance, namely the absence of ADH, has been introduced. This review will attempt to present a comprehensive description of the state of sodium and potassium balance in the DI rat. Although some data exist on the handling of other electrolytes 51, 54 these have not'been studied extensively. Mention will also be made of the multiple factor~ thjlt may influence elec trolyte balance in the Brattleboro rat. New data, obtained by Opava-Stitzer and Fernandez-Repollet, will be included when relevaqt.
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عنوان ژورنال:
- Annals of the New York Academy of Sciences
دوره 394 شماره
صفحات -
تاریخ انتشار 1982